key specifications
Indications:
Prenatal:
Induction of labor for patients with medical indications (such as maternal-fetal blood incompatibility, diabetic mothers, gestational hypertension, during or near labor), stimulation and enhancement of labor (in the absence of effective uterine contractions during labor), adjunctive therapy in managing incomplete or unavoidable abortions.
Postpartum:
To control postpartum hemorrhage
If you have any of the following, discuss them with your doctor or pharmacist before taking the drug:
Any allergies to the drug or its ingredients
Suffering from other diseases
Use of other medications
Pregnancy and breastfeeding
Depending on your response to treatment, your doctor may prescribe a higher or lower dose.
Avoid taking more than your doctor has prescribed.
The dosage is determined by your doctor, but the usual dosage is as follows:
Adult Use:
Adjunctive Treatment of Abortion (Incomplete, Inevitable, or Elective Abortion):
10 Units as an IV infusion after rapid suction or curettage (to help the uterus contract)
Induction of Labor:
(Note: Intravenous (IV) administration requires the use of an infusion pump.)
Initial Dose: 0.5 to 1 mL/min
Dose Adjustment: Gradually increase the dose by 1 to 2 mL/min every 30 to 60 minutes to establish the desired contraction pattern; the dose may be reduced in the same incremental manner after the desired number of contractions is achieved or the cervix is dilated to 5 to 6 cm.
Maintenance Dose: Infusion rate up to 6 mL/min; doses greater than 9 to 10 mL/min are rarely needed.
A higher dose regimen (e.g., starting at 2 to 6 mIU/min) with larger incremental doses (e.g., 1 to 6 mIU/min) has also been suggested.
Discontinuation of therapy:
In the event of uterine hyperactivity or fetal distress, discontinue the oxytocin infusion immediately. If uterine contractions become too intense and forceful, the infusion should be discontinued immediately.
Postpartum uterine hemorrhage:
Intravenous (IV): The optimal dose is not fully established, but is usually 5 to 10 units infused slowly, with a maintenance dose of 10 units per hour.
Intramuscular (IM): 10 units intramuscularly after placental delivery.
Rapid bolus intravenous doses are not recommended.
Use in children: This drug is not indicated for use in children.
Use in the elderly: This drug is not indicated for use in the elderly.